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TNF- caused mitochondrial mPTP opening, apoptosis, and downregulation of phosphatase and tensin homolog signal, resulting in excessive Bnip3-dependent mitophagy and mitochondrial dysfunction [79, 80]

Please consult with your healthcare professional before starting any new supplement

564C , 8388 (2014)

An RCT in 72 patients with NAFLD found that NAC (600 mg twice daily) for 3 months significantly improved liver enzymes (ALT, AST) and markers of oxidative stress compared to control, though it did not significantly improve liver histology on biopsy (Khoshbaten et al., Hepat Mon, 2010) [33]

What makes ALA remarkable among antioxidants is its amphipathic nature it dissolves in both water and fat, allowing it to operate in virtually every tissue and cellular compartment throughout the body