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Developing TME-responsive targeted delivery systems and combining ferroptosis inducers with immune checkpoint inhibitors or CAF inhibitors can enhance therapeutic efficacy and reduce toxicity ( In summary, ferroptosis holds great potential for the treatment of digestive tract tumors, but its clinical translation relies on in-depth deciphering of the interaction mechanisms between TME, immunity, and ferroptosis

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Macrophage-encapsulated OMVs have been utilized to deliver Ce6 and doxorubicin to the 4T1 breast cancer cell line (146)