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[19] As discussed above, even though various attempts have been made to find an efficient and economical method to prepare L-carnitine, conventional methods have various disadvantages and problems, such as great difficulty to achieve high yield and high optical purity, complicated production processes, and high production costs due to high-temperature and high-pressure reaction conditions, which consequently lead to a difficulty of practical application thereof

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[DOI] [PubMed] [Google Scholar] Koeth RA, et al

Metabolic endotoxemia initiates obesity and insulin resistance