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Despite small differences were observed between recombinant and endogenous human G-CSF, the incidence of ADA production in patients treated with recombinant G-CSF has been reported in some clinical phase I studies 24

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EC-SOD (SOD3) is predominantly found in the lungs and is located primarily in the extracellular space

Gln, a nonessential amino acid abundant in the bloodstream, along with its metabolites lutamate and ketoglutarate (-KG), serves as a vital source of carbon and nitrogen, providing essential raw materials for the synthesis of nucleotides and amino acids ( Although some Gln metabolic inhibitors have entered clinical trials, the heterogeneity among tumors complicates their effectiveness