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Besides diabetes and high blood pressure, the following additional health conditions may also contribute to CKD 1 : Cardiovascular disease Systemic or kidney infections Immune system conditions (eg, lupus) Inflammation of the glomeruli (tiny filters) in the kidneys Inherited kidney disease (eg, polycystic kidney disease) Congenital defects (eg, kidney malformation, urinary tract obstruction) Medications and toxins (eg, prolonged medication, chemical, or street drug exposure) Factors such as those described above and various others can contribute to the decline in kidney function characteristic of CKD

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Its ability to promote collagen synthesis and new blood vessel formation at the injury site makes it particularly relevant for the knee's complex connective tissue structures