Lastly, taking supplemental doses of B12 higher than 100-150% of the RDA can trigger breakouts in acne-prone people.
doi:10.1007/s00125-007-0793-y
If we look at people undergoing a type of bariatric surgery that messes with B12 absorption, we start seeing problems within just a few months in terms of impaired metabolism, a rise in methylmalonic acid and homocysteine, two compounds that are normally cleared in part by B12

CC BY-ND: You are free to share copy and redistribute the material in any medium or format for any purpose, even commercially under these conditions: Attribution is required If you remix, transform or build upon the material, you may not distribute the modified material CC BY NC: You are free to share copy and redistribute the material in any medium or format adapt remix, transform, and build upon the material under these conditions: Attribution is required NonCommercial: you may not use the material for commercial purposes CC BY NC SA: You are free to share copy and redistribute the material in any medium or format under these conditions: Attribution is required You may not use the material for commercial purposes If you remix, transform or build upon the material, you may not distribute the modified material You may not apply legal terms or technological measures that legally restrict others from doing anything the license permits CC BY NC ND: You are free to share copies and redistribute the material in any medium or format under these conditions: Attribution is required NonCommercial: you may not use the material for commercial purposes

Rheumatoid Arthritis: An autoimmune disease that causes inflammation in the elbow joint lining, leading to chronic pain and swelling