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In summary, given that xenobiotic toxicities and drug efficacies might be influenced by the gut microbial GUS composition in the gut and by their substrate specificity, the structure-activity relationship studies of GUSs at molecular level are needed to understand the inter-individual variation of drug responses

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An intervention approach that can provide numerous possible targets is innate immune responses via cell surface molecules and soluble mediators that further modulate adaptive immune responses

Iron catalyzes the formation of ROS via the Fenton reaction 48

Dietary habits of subjects were determined using a questionnaire similar to that conducted by the Atherosclerotic Risk in Community (ARIC) study (59)